diff --git a/src/OpenTelemetry.AutoInstrumentation.Loader/Loader.NetFramework.cs b/src/OpenTelemetry.AutoInstrumentation.Loader/Loader.NetFramework.cs
index 5016955aa2..85b57fc019 100644
--- a/src/OpenTelemetry.AutoInstrumentation.Loader/Loader.NetFramework.cs
+++ b/src/OpenTelemetry.AutoInstrumentation.Loader/Loader.NetFramework.cs
@@ -33,7 +33,30 @@ private static string ResolveManagedProfilerDirectory()
             return null;
         }
 
-        Logger.Debug("Requester [{0}] requested [{1}]", args?.RequestingAssembly?.FullName ?? "<null>", args?.Name ?? "<null>");
+        Logger.Debug("Requester [{0}] requested [{1}]", args.RequestingAssembly?.FullName ?? "<null>", args.Name ?? "<null>");
+
+        // All MongoDB* are signed and does not follow https://learn.microsoft.com/en-us/dotnet/standard/library-guidance/versioning#assembly-version
+        // There is no possibility to automatically redirect from 2.28.0 to 2.29.0.
+        // Loading assembly and ignoring this version.
+        if (assemblyName.StartsWith("MongoDB", StringComparison.OrdinalIgnoreCase) &&
+            (string.Equals(assemblyName, "MongoDB.Driver.Core", StringComparison.OrdinalIgnoreCase) ||
+            string.Equals(assemblyName, "MongoDB.Bson", StringComparison.OrdinalIgnoreCase) ||
+            string.Equals(assemblyName, "MongoDB.Libmongocrypt", StringComparison.OrdinalIgnoreCase)))
+        {
+            try
+            {
+                var mongoAssembly = Assembly.Load(assemblyName);
+                Logger.Debug<string, bool>("Assembly.Load(\"{0}\") succeeded={1}", assemblyName, mongoAssembly != null);
+                return mongoAssembly;
+            }
+            catch (Exception ex)
+            {
+                Logger.Debug(ex, "Assembly.Load(\"{0}\") Exception: {1}", assemblyName, ex.Message);
+            }
+
+            return null;
+        }
+
         var path = Path.Combine(ManagedProfilerDirectory, $"{assemblyName}.dll");
         if (File.Exists(path))
         {