diff --git a/static/app/actionCreators/uptime.tsx b/static/app/actionCreators/uptime.tsx
new file mode 100644
index 00000000000000..bf61ff38bc1840
--- /dev/null
+++ b/static/app/actionCreators/uptime.tsx
@@ -0,0 +1,44 @@
+import * as Sentry from '@sentry/react';
+
+import {
+  addErrorMessage,
+  addLoadingMessage,
+  clearIndicators,
+} from 'sentry/actionCreators/indicator';
+import type {Client} from 'sentry/api';
+import {t} from 'sentry/locale';
+import type RequestError from 'sentry/utils/requestError/requestError';
+import type {UptimeRule} from 'sentry/views/alerts/rules/uptime/types';
+
+export async function updateUptimeRule(
+  api: Client,
+  orgId: string,
+  uptimeMonitor: UptimeRule,
+  data: Partial<UptimeRule>
+): Promise<UptimeRule | null> {
+  addLoadingMessage();
+
+  try {
+    const resp = await api.requestPromise(
+      `/projects/${orgId}/${uptimeMonitor.projectSlug}/uptime/${uptimeMonitor.id}/`,
+      {method: 'PUT', data}
+    );
+    clearIndicators();
+    return resp;
+  } catch (err) {
+    const respError: RequestError = err;
+    const updateKeys = Object.keys(data);
+
+    // If we are updating a single value in the monitor we can read the
+    // validation error for that key, otherwise fallback to the default error
+    const validationError =
+      updateKeys.length === 1
+        ? (respError.responseJSON?.[updateKeys[0]!] as any)?.[0]
+        : undefined;
+
+    Sentry.captureException(err);
+    addErrorMessage(validationError ?? t('Unable to update uptime monitor.'));
+  }
+
+  return null;
+}
diff --git a/static/app/views/alerts/list/rules/combinedAlertBadge.tsx b/static/app/views/alerts/list/rules/combinedAlertBadge.tsx
index e14ba061bf8d5a..ee515b71d53ad9 100644
--- a/static/app/views/alerts/list/rules/combinedAlertBadge.tsx
+++ b/static/app/views/alerts/list/rules/combinedAlertBadge.tsx
@@ -61,7 +61,7 @@ export default function CombinedAlertBadge({rule}: Props) {
     const {statusText, incidentStatus} = UptimeStatusText[rule.uptimeStatus];
     return (
       <Tooltip title={tct('Uptime Alert Status: [statusText]', {statusText})}>
-        <AlertBadge status={incidentStatus} />
+        <AlertBadge status={incidentStatus} isDisabled={rule.status === 'disabled'} />
       </Tooltip>
     );
   }
diff --git a/static/app/views/alerts/rules/uptime/details.spec.tsx b/static/app/views/alerts/rules/uptime/details.spec.tsx
index e2e9775f5d90c2..f566dde55b3f38 100644
--- a/static/app/views/alerts/rules/uptime/details.spec.tsx
+++ b/static/app/views/alerts/rules/uptime/details.spec.tsx
@@ -1,7 +1,7 @@
 import {UptimeRuleFixture} from 'sentry-fixture/uptimeRule';
 
 import {initializeOrg} from 'sentry-test/initializeOrg';
-import {render, screen} from 'sentry-test/reactTestingLibrary';
+import {render, screen, userEvent} from 'sentry-test/reactTestingLibrary';
 
 import UptimeAlertDetails from './details';
 
@@ -56,4 +56,57 @@ describe('UptimeAlertDetails', function () {
       await screen.findByText('The uptime alert rule you were looking for was not found.')
     ).toBeInTheDocument();
   });
+
+  it('disables and enables the rule', async function () {
+    MockApiClient.addMockResponse({
+      url: `/projects/${organization.slug}/${project.slug}/uptime/2/`,
+      statusCode: 404,
+    });
+    MockApiClient.addMockResponse({
+      url: `/projects/${organization.slug}/${project.slug}/uptime/1/`,
+      body: UptimeRuleFixture({name: 'Uptime Test Rule'}),
+    });
+
+    render(
+      <UptimeAlertDetails
+        {...routerProps}
+        params={{...routerProps.params, uptimeRuleId: '1'}}
+      />,
+      {organization}
+    );
+    await screen.findByText('Uptime Test Rule');
+
+    const disableMock = MockApiClient.addMockResponse({
+      url: `/projects/${organization.slug}/${project.slug}/uptime/1/`,
+      method: 'PUT',
+      body: UptimeRuleFixture({name: 'Uptime Test Rule', status: 'disabled'}),
+    });
+
+    await userEvent.click(
+      await screen.findByRole('button', {
+        name: 'Disable this uptime rule and stop performing checks',
+      })
+    );
+
+    expect(disableMock).toHaveBeenCalledWith(
+      expect.anything(),
+      expect.objectContaining({data: {status: 'disabled'}})
+    );
+
+    const enableMock = MockApiClient.addMockResponse({
+      url: `/projects/${organization.slug}/${project.slug}/uptime/1/`,
+      method: 'PUT',
+      body: UptimeRuleFixture({name: 'Uptime Test Rule', status: 'active'}),
+    });
+
+    // Button now re-enables the monitor
+    await userEvent.click(
+      await screen.findByRole('button', {name: 'Enable this uptime rule'})
+    );
+
+    expect(enableMock).toHaveBeenCalledWith(
+      expect.anything(),
+      expect.objectContaining({data: {status: 'active'}})
+    );
+  });
 });
diff --git a/static/app/views/alerts/rules/uptime/details.tsx b/static/app/views/alerts/rules/uptime/details.tsx
index 9a72cb71fb1429..f1458f5fb441c0 100644
--- a/static/app/views/alerts/rules/uptime/details.tsx
+++ b/static/app/views/alerts/rules/uptime/details.tsx
@@ -1,5 +1,6 @@
 import styled from '@emotion/styled';
 
+import {updateUptimeRule} from 'sentry/actionCreators/uptime';
 import ActorAvatar from 'sentry/components/avatar/actorAvatar';
 import Breadcrumbs from 'sentry/components/breadcrumbs';
 import {LinkButton} from 'sentry/components/button';
@@ -20,18 +21,28 @@ import {t} from 'sentry/locale';
 import {space} from 'sentry/styles/space';
 import type {RouteComponentProps} from 'sentry/types/legacyReactRouter';
 import getDuration from 'sentry/utils/duration/getDuration';
-import {type ApiQueryKey, useApiQuery} from 'sentry/utils/queryClient';
+import {
+  type ApiQueryKey,
+  setApiQueryData,
+  useApiQuery,
+  useQueryClient,
+} from 'sentry/utils/queryClient';
+import useApi from 'sentry/utils/useApi';
 import useOrganization from 'sentry/utils/useOrganization';
 import useProjects from 'sentry/utils/useProjects';
 import type {UptimeRule} from 'sentry/views/alerts/rules/uptime/types';
 
+import {StatusToggleButton} from './statusToggleButton';
 import {UptimeIssues} from './uptimeIssues';
 
 interface UptimeAlertDetailsProps
   extends RouteComponentProps<{projectId: string; uptimeRuleId: string}, {}> {}
 
 export default function UptimeAlertDetails({params}: UptimeAlertDetailsProps) {
+  const api = useApi();
   const organization = useOrganization();
+  const queryClient = useQueryClient();
+
   const {projectId, uptimeRuleId} = params;
 
   const {projects, fetching: loadingProject} = useProjects({slugs: [projectId]});
@@ -69,6 +80,14 @@ export default function UptimeAlertDetails({params}: UptimeAlertDetailsProps) {
     );
   }
 
+  const handleUpdate = async (data: Partial<UptimeRule>) => {
+    const resp = await updateUptimeRule(api, organization.slug, uptimeRule, data);
+
+    if (resp !== null) {
+      setApiQueryData(queryClient, queryKey, resp);
+    }
+  };
+
   return (
     <Layout.Page>
       <SentryDocumentTitle title={`${uptimeRule.name} — Alerts`} />
@@ -97,6 +116,11 @@ export default function UptimeAlertDetails({params}: UptimeAlertDetailsProps) {
         </Layout.HeaderContent>
         <Layout.HeaderActions>
           <ButtonBar gap={1}>
+            <StatusToggleButton
+              uptimeRule={uptimeRule}
+              onToggleStatus={status => handleUpdate({status})}
+              size="sm"
+            />
             <LinkButton
               size="sm"
               icon={<IconEdit />}
diff --git a/static/app/views/alerts/rules/uptime/statusToggleButton.tsx b/static/app/views/alerts/rules/uptime/statusToggleButton.tsx
new file mode 100644
index 00000000000000..40792fce7ac09a
--- /dev/null
+++ b/static/app/views/alerts/rules/uptime/statusToggleButton.tsx
@@ -0,0 +1,42 @@
+import type {BaseButtonProps} from 'sentry/components/button';
+import {Button} from 'sentry/components/button';
+import {IconPause, IconPlay} from 'sentry/icons';
+import {t} from 'sentry/locale';
+import type {ObjectStatus} from 'sentry/types/core';
+
+import type {UptimeRule} from './types';
+
+interface StatusToggleButtonProps extends Omit<BaseButtonProps, 'onClick'> {
+  onToggleStatus: (status: ObjectStatus) => Promise<void>;
+  uptimeRule: UptimeRule;
+}
+
+export function StatusToggleButton({
+  uptimeRule,
+  onToggleStatus,
+  ...props
+}: StatusToggleButtonProps) {
+  const {status} = uptimeRule;
+  const isDisabled = status === 'disabled';
+
+  const Icon = isDisabled ? IconPlay : IconPause;
+
+  const label = isDisabled
+    ? t('Enable this uptime rule')
+    : t('Disable this uptime rule and stop performing checks');
+
+  return (
+    <Button
+      icon={<Icon />}
+      aria-label={label}
+      title={label}
+      onClick={async () => {
+        await onToggleStatus(isDisabled ? 'active' : 'disabled');
+        // TODO(epurkhiser): We'll need a hook here to trigger subscription
+        // refesh in getsentry when toggling uptime monitors since it will
+        // consume quota.
+      }}
+      {...props}
+    />
+  );
+}
diff --git a/static/app/views/alerts/rules/uptime/types.tsx b/static/app/views/alerts/rules/uptime/types.tsx
index a4c7073bd657c7..96086ed5ee074b 100644
--- a/static/app/views/alerts/rules/uptime/types.tsx
+++ b/static/app/views/alerts/rules/uptime/types.tsx
@@ -1,4 +1,4 @@
-import type {Actor} from 'sentry/types/core';
+import type {Actor, ObjectStatus} from 'sentry/types/core';
 
 export enum UptimeMonitorStatus {
   OK = 1,
@@ -22,6 +22,7 @@ export interface UptimeRule {
   name: string;
   owner: Actor;
   projectSlug: string;
+  status: ObjectStatus;
   timeoutMs: number;
   traceSampling: boolean;
   uptimeStatus: UptimeMonitorStatus;
diff --git a/tests/js/fixtures/uptimeRule.ts b/tests/js/fixtures/uptimeRule.ts
index 7aec0d2004c893..bacbfe5e134fb8 100644
--- a/tests/js/fixtures/uptimeRule.ts
+++ b/tests/js/fixtures/uptimeRule.ts
@@ -11,6 +11,7 @@ export function UptimeRuleFixture(params: Partial<UptimeRule> = {}): UptimeRule
     projectSlug: 'project-slug',
     environment: 'prod',
     uptimeStatus: UptimeMonitorStatus.OK,
+    status: 'active',
     timeoutMs: 5000,
     url: 'https://sentry.io/',
     headers: [],